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. 2020 Jun 9;10:9313. doi: 10.1038/s41598-020-66285-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) SPECT/CT images of mice bearing LNCaP lung microtumors collected at different time points after injection of 37 MBq dose of ¹⁷⁷Lu-iPSMA (upper panels) and ¹⁷⁷Lu-scFvD2B (lower panels). Images are representative of one out three mice selected for each group. (B) ¹⁷⁷Lu-scFvD2B and ¹⁷⁷Lu-iPSMA tumor kinetic curves obtained from the pulmonary microtumors data. CT and SPECT single images, as well as axial and sagittal sections displaying the microtumor locations of each mouse, are shown in Supplementary Information (see Figs. S9–S32).