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. 2020 Apr 15;122(12):1848–1856. doi: 10.1038/s41416-020-0829-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Univariate smoothed hazard rate and cumulative hazard by cancer stage in patients with and without unexpected weight loss. In men, 54 cancers (0.2%) were diagnosed with late-stage cancer in 25,551 men with unexpected weight loss in the first 3 months rising to 66 (0.3%) cases over the first 6 months compared with 46 (0.04%) of 10,7706 men without unexpected weight loss in the first 3 months rising to 88 (0.08%) by 6 months. In women, 37 late-stage cancers (0.1%) were diagnosed in 36,057 women with unexpected weight loss in the first 3 months rising to 52 (0.1%) over 6 months compared with 38 (0.02%) in 145,203 women without unexpected weight loss over 3 months rising to 75 (0.05%) over 6 months.