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. 2020 Jun 9;10:9330. doi: 10.1038/s41598-020-66458-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Saroglitazar treatment reduces lipotoxic compounds in the liver. Endogenous metabolic profiles of liver samples taken from mice fed with CDNW or WDSW treated with/without saroglitazar were determined using ultra high performance liquid chromatography- mass spectrometry (UHPLC-MS). Box plots of (A) ceramide, (B) sphingomyelin, (C) phosphatidylcholine, (D) phosphatidylethanolamine. Data are expressed as the mean ± SEM for 6–12 mice per group. ^#p < 0.05, ^##p < 0.001 compared to CDNW; *p < 0.05, **p < 0.001 compared to WDSW, vehicle control.