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. 2020 Jun 9;10:9337. doi: 10.1038/s41598-020-65989-9

Table 2.

List of most frequently prescribed medications with ACB score.

ACB score 1 (% of patients with prescription)
All (N = 378.716) Older adults (N = 148.706) Adults (N = 180.413) Children (N = 49.597)
loratadine 26.3 11.8 26.1 70.8
alprazolam 17.1 19.7 19.5 0.3
furosemide 14.6 32.0 4.3 <1.0
desloratadine 11.9 4.7 17.4 14.1
warfarin 7.2 16.2 1.9 <1.0
diazepam 7.0 7.2 8.4 <1.0
ranitidine 7.0 7.2 8.4 <1.0
cetirizine 6.6 3.8 7.7 11.3
metoprolol 3.7 6.9 2.1 <1.0
risperidone 3.2 4.5 2.5 1.6
levocetirizine 3.0 <1.0 4.2 3.8
nifedipine 2.9 5.4 1.7 <1.0
trazodone 3.0 2.8 4.1 <1.0
venlafaxine 2.0 1.4 3.0 <1.0
isosorbide mononitrate 2.0 4.8 <1.0 <1.0
bupropion <1.0 <1.0 2.2 <1.0
aripiprazole <1.0 <1.0 1.7 <1.0
haloperidol <1.0 1.9 <1.0 <1.0
fentanyl <1.0 2.3 <1.0 <1.0
captopril <1.0 2.0 <1.0 <1.0
ACB score 2 (% of patients with prescription)
All (N = 8.109) Older adults (N = 3.095) Adults (N = 4.694) Children (N = 320)
carbamazepine 72.4 74.9 73.3 36.3
oxcarbazepine 14.9 11.0 14.1 64.4
levomepromazine 8.8 7.5 10.4 0
amantadine 5.3 7.5 4.2 0
ACB score 3 (% of patients with prescription)
All (N = 105.585) Older adults (N = 43.901) Adults (N = 58.837) Children (N = 2.847)
quetiapine 31.5 41.2 25.3 8.4
trospium 31.0 21.2 38.0 39.8
paroxetine 13.5 10.2 16.6 1.3
olanzapine 8.6 6.0 10.8 3.7
solifenacin 6.1 9.3 3.9 0.3
amitriptyline 4.9 4.7 5.2 0.6
tamsulosin and solifenacin 4.6 7.4 2.7 0
atropine 2.7 1.8 1.5 42.8
clozapine 2.6 1.6 3.6 0.1
fesoterodine 1.6 1.3 0.6 0.2
darifenacin 1.5 2.6 0.8 0
tolterodine 0.7 0.9 0.3 4.1
scopolamine <0.1 <0.1 <0.1 0

*Numbers in bold represent prevalence above 5%.

Of note: Each patient may have received prescriptions for two medications with mild anticholinergic burden in 2018, eg. loratadine and alprazolam, and therefore appeared in the calculation twice. Hence, the percentage sum in each category may be higher than 100.