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. 2020 Apr 30;122(12):1837–1847. doi: 10.1038/s41416-020-0827-5

Fig. 6. Effect of SCD1 inhibition on gastric cancer cell tumorigenicity and metastasis in vivo.

Fig. 6

a In vivo assay of the effect of SCD1 suppression and chemotherapy on gastric cancer cell tumorigenicity. b Statistical analysis of tumour growth volume of xenografts formed by modified HSC034 cells in 4 weeks (values represent the mean ± SD of three independent experiments. **p < 0.01 and ***p < 0.001). c Representative images of haematoxylin and eosin (HE) staining of mice lung and liver tissues following different cell treatments (scale bar, 10 μm in black and 25 μm in red; arrow, metastatic sites). d The ratios of lung and liver metastatic sites detected after tail-vein injection by control or modified HSC034 cells. e Proposed schematic mechanism of SCD1 regulating stem-like properties in gastric cancer stem cells via Hippo/YAP pathway and the effect of SCD1-targeted inhibition.