Table 3.
Hazard ratio (HR) and corresponding 95% confidence interval (CI)a for progression-free survival and overall survival according to socio-demographic and clinical characteristics.
| Pts | Progression-free survivalb | Overall survival | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n | (%) | HR | (95% CI) | n | (%) | HR | (95% CI) | ||
| Gender | |||||||||
| Female | 35 | 16 | (45.7) | Ref. | 15 | (42.9) | Ref. | ||
| Male | 95 | 63 | (66.3) | 0.86 | (0.47–1.56) | 60 | (63.2) | 0.76 | (0.41–1.41) |
| Age (years) | |||||||||
| <65 | 68 | 42 | (61.8) | Ref. | 39 | (57.4) | Ref. | ||
| ≥65 | 62 | 37 | (59.7) | 1.33 | (0.83–2.11) | 36 | (58.1) | 1.60 | (0.99–2.59) |
| Year of diagnosis | |||||||||
| 2000–2006 | 36 | 28 | (77.8) | Ref | 28 | (77.8) | Ref | ||
| 2007–2012 | 42 | 33 | (78.6) | 1.84 | (1.05–3.23) | 30 | (71.4) | 1.41 | (0.80–2.49) |
| 2013–2018 | 52 | 18 | (34.6) | 0.83 | (0.44–1.55) | 17 | (32.7) | 0.90 | (0.47–1.72) |
| Cancer subsite | |||||||||
| Base of tongue | 28 | 11 | (39.3) | Ref. | 10 | (35.7) | Ref. | ||
| Tonsil | 84 | 57 | (67.9) | 1.09 | (0.53–2.24) | 54 | (64.3) | 1.09 | (0.52–2.27) |
| Other | 18 | 11 | (61.1) | 1.02 | (0.41–2.56) | 11 | (61.1) | 1.15 | (0.46–2.89) |
| TNM stage (7th ed.)c | |||||||||
| I-II | 13 | 7 | (53.9) | Ref. | 7 | (53.9) | Ref. | ||
| III | 23 | 14 | (60.9) | 1.35 | (0.53–3.42) | 14 | (60.9) | 1.49 | (0.59–3.80) |
| IV | 94 | 58 | (61.7) | 1.89 | (0.83–4.28) | 54 | (57.5) | 1.81 | (0.80–4.12) |
| TNM stage (8th ed.) | |||||||||
| I-II | 38 | 12 | (31.6) | Ref. | 12 | (31.6) | Ref. | ||
| III | 27 | 17 | (63.0) | 2.82 | (1.29–6.18) | 16 | (59.3) | 2.62 | (1.19–5.76) |
| IV | 65 | 50 | (76.9) | 4.65 | (2.27–9.49) | 47 | (72.3) | 3.53 | (1.76–7.09) |
| Grading | |||||||||
| G1-G2 | 63 | 48 | (76.2) | Ref. | 45 | (71.4) | Ref. | ||
| G3 | 55 | 28 | (50.9) | 0.57 | (0.57–0.95) | 27 | (49.1) | 0.79 | (0.47–1.34) |
| Tobacco smoking | |||||||||
| Never | 26 | 11 | (42.3) | Ref. | 10 | (38.5) | Ref. | ||
| Former | 30 | 19 | (63.3) | 1.11 | (0.49–2.55) | 18 | (60.0) | 0.99 | (0.42–2.31) |
| Current | 74 | 49 | (66.2) | 1.12 | (0.52–2.41) | 47 | (63.5) | 1.27 | (0.58–2.79) |
| Alcohol drinking | |||||||||
| Never | 54 | 18 | (33.3) | Ref. | 17 | (31.5) | Ref. | ||
| Former | 13 | 10 | (76.9) | 1.68 | (0.75–3.80) | 9 | (69.2) | 1.93 | (0.82–4.54) |
| Current | 61 | 50 | (82.0) | 2.59 | (1.45–4.64) | 48 | (78.7) | 3.18 | (1.74–5.79) |
aAdjusted for gender, age, year of diagnosis, TNM stage (8th ed.), and alcohol drinking. bOne patient was not evaluable for progression-free survival. cAdjusted for gender, age, year of diagnosis, and alcohol drinking.