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. 2020 Jun 3;10:238. doi: 10.3389/fcimb.2020.00238

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Copyright © 2020 Samir, Malireddi and Kanneganti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The molecular components of the PANoptosome and the human health significance of PANoptosis. (A) Proposed domains of PANoptosome components required for complex assembly in response to various stimuli. PANoptosome assembly is mediated by key molecular motifs collectively called death fold domains. Genetic evidence suggests that PANoptosome activation is inhibited by TAK1, PSTPIP2, SHARPIN, HOIP, HOIL-1, and A20. (B) Defects in the PANoptosome components have been implicated in a range of human diseases.