Table 1.
A list of PANoptosome components and associated human diseases.
| PANoptosome component | Associated disease(s) | References |
|---|---|---|
| NLRP3 | Cryopyrin-associated periodic syndrome, Familial cold urticaria, Muckle-Wells syndrome | Hoffman et al., 2001; Aganna et al., 2002; Dodé et al., 2002; Rösen-Wolff et al., 2003; Hawkins et al., 2004; Verma et al., 2010; Kuemmerle-Deschner et al., 2011; Rowczenio et al., 2013; Alejandre et al., 2014 |
| Chronic infantile neurological cutaneous and articular syndrome | Aksentijevich et al., 2002; Feldmann et al., 2002; Neven et al., 2004; Jesus et al., 2008 | |
| Crohn's disease | Schoultz et al., 2009; Zhang H. et al., 2014 | |
| RIPK3 | Steatohepatitis | Roychowdhury et al., 2013; Wang et al., 2016 |
| RIPK1 | Adenocarcinoma of large intestine | Greenman et al., 2007 |
| ASC | Liver carcinoma | Zhang et al., 2007 |
| Colorectal carcinoma | Yokoyama et al., 2003; Ohtsuka et al., 2006; Riojas et al., 2007 | |
| Non-small cell lung carcinoma | Rosell et al., 2002; Virmani et al., 2003; Machida et al., 2006; Zhang et al., 2006 | |
| CASP1 | Multiple sclerosis | Furlan et al., 1999; Huang et al., 2004; Peelen et al., 2015 |
| CASP8 | Autoimmune lymphoproliferative syndrome type 2B | Chun et al., 2002 |
| Breast carcinoma | MacPherson et al., 2004; Michailidou et al., 2017 | |
| Liver carcinoma | Soung et al., 2005 | |
| TAK1 | Cardiospondylocarpofacial syndrome | Le Goff et al., 2016 |
| Frontometaphyseal dysplasia | Wade et al., 2016 | |
| Malignant neoplasm of prostate | Liu et al., 2007 | |
| A20 | Autoinflammatory syndrome, familial, Behcet-like | Shigemura et al., 2016; Zhou et al., 2016 |
| Rheumatoid arthritis | Lodolce et al., 2010; Stahl et al., 2010; Matmati et al., 2011; Lee et al., 2012; Perkins et al., 2012; Prahalad et al., 2013; Hao et al., 2014; Kim et al., 2014; Zhang X. et al., 2014; Hoffjan et al., 2015; Shen et al., 2017 | |
| Systemic lupus erythematosus | Adrianto et al., 2011; Fan et al., 2011 | |
| Psoriasis | Nair et al., 2009; Strange et al., 2010; Jiang et al., 2012; Tsoi et al., 2012; Indhumathi et al., 2015 | |
| Sjögren's syndrome | Sisto et al., 2011 | |
| HOIL-1 | Polyglucosan body myopathy 1 with or without immunodeficiency | Nilsson et al., 2013 |
| Rhabdomyolysis | Wang et al., 2013 | |
| PSTPIP2 | Chronic recurrent multifocal osteomyelitis | El-Shanti and Ferguson, 2007; Ferguson and El-Shanti, 2007 |