Table 1.

List of distinctive features of IAVs and BatIVs.

	IAVs	BatIVs
Known hosts	Birds, humans, swine, equine, and marine mammals	New World bats
Clinical manifestation	Mild to severe respiratory disease to humans and birds, cause outbreaks/epidemics, and sporadically pandemics	Asymptomatic (unclear)
Cell surface receptors/entry factors	Sialic acids	MHC-II
Role of haemagglutinin	Cell attachment/entry	Cell entry
Role of neuraminidase	Sialidase activity	Unknown
Culture in embryonated chicken eggs	Yes (usually)	No
Agglutination of red blood cells	Yes (usually)	No
Genetic drift	Yes	Yes
Genetic reassortment	Yes	Yes (not with IAVs)
Main transmission routes	Respiratory droplets, direct contact/fecal-oral	Fecal-oral (unclear)