Table 2.

Summary of Grade > 3 CTCAEs occurring in at least 5% patients.

	CON (n = 74)						SEQ (n = 68)
	Grade 3,		Grade 4,		Grade 5,		Grade 3,		Grade 4,		Grade 5,
	n	%	n	%	n	%	n	%	n	%	n	%
No. of patients experiencing worst-grade AEs	44	59	12	16	5	7	29	43	27	40	10	15
Fatigue	15	20	0	0	0	0	16	24	0	0	0	0
Neutrophil count decreased	20	27	4	5	0	0	19	28	21	31	0	0
Nausea	2	3	0	0	0	0	6	9	0	0	0	0
Diarrhoea	4	5	0	0	0	0	6	9	0	0	0	0
Anaemia	4	5	0	0	0	0	8	12	0	0	0	0
Vomiting	8	11	0	0	0	0	5	7	0	0	0	0
Abdominal pain	4	5	0	0	0	0	3	4	0	0	0	0
Platelet count decreased	7	9	1	1	0	0	2	3	1	1	0	0
White blood cell decreased	1	1	2	3	0	0	4	6	2	3	0	0
Lung infection	4	5	0	0	3	4	4	6	0	0	2	3
Febrile neutropaenia	6	8	2	3	1	1	7	10	3	4	1	1
GGT increased	5	7	2	3	0	0	2	3	1	1	0	0
Alanine aminotransferase increased	2	3	0	0	0	0	5	7	1	1	0	0
Thromboembolic event	2	3	0	0	0	0	4	6	0	0	1	1
Bilirubin increased	1	1	0	0	0	0	8	12	0	0	0	0
Sepsis	0	0	5	7	0	0	0	0	4	6	2	3
Dehydration	3	4	0	0	0	0	5	7	0	0	0	0
Hypotension	3	4	0	0	0	0	4	6	0	0	0	0
Other grade 5 AEs	1 gallbladder obstruction						1 pneumonitis, 1 colitis, 1 hypoxia and 1 cholangitis