Fig. 4. Effect of FKBP51s downregulation on expression of monocyte markers associated with positive (HLA-DR, CD80) or negative (PD-L1, IL-10, ARG1 and MSR1) lymphocyte co-stimulation.

a QPCR measure of ARG1 and MSR1 transcript levels in RNA extracted by healthy donors’ macrophages downmodulated or not for FKBP51s. Values of FKBP51s-silenced monocytes were expressed as fold change, using the non-silenced monocyte value as reference sample (=1). b Graphic representation of flow cytometric values of expression of CD80, PD-L1, IL-10 and HLA-DR in macrophages downmodulated or not for FKBP51s, from four healthy donors, and c representative flow cytometry histograms.