Figure 3.

KSiNPs activate macrophages to differentiate into M2 phenotypes and promote wound healing. (A) Schematic of the mechanism by which KSiNPs promote chronic wound healing. (B) Immunofluorescence identification of macrophages in each experimental group 7 days post-operation. Scale bars, 20 μm. (C) Quantitative analysis of the results from (B), showing that the proportion of M2 macrophages in the KSiNP group increased. *P < 0.05, **P < 0.01. (D) Flow cytometry detection of macrophage activation status in different groups of wounds on day 7. Reproduced with permission from Gan et al. (2019).