Figure 5.

Silencing the MMP-9 gene accelerates the healing of chronic wounds through ECM remodeling. (A) Chemical structures of the materials used in the dressing, and schematic diagram of the double coatings fabricated by LbL self-assembly; X and Y represent the number of layers of Poly 2/DS and CS/siRNA, respectively. (B) Schematic of the in vivo experiments. (C) Post-operative photographs of wounds areas. Scale bar, 5 mm. (D) Sirius Red staining images of Col tissue infiltration and fusion with wound edges. UD, undamaged dermis. GT, granulation tissue. Scale bars, 75 μm. Reproduced with permission from Castleberry et al. (2016).