Figure 1.
Related cell–cell cross-talk and pathways of increased levels of TGF-β1 mRNA in extracellular vesicles involved in diabetic nephropathy (DN). High glucose stimulated different cells, such as GEC, GMC, RPTC, and Mφ, to express TGF-β1 mRNA and promote DN development. Different colors in the figure represent different cell–cell cross-talks. GEC, glomerular endothelial cells; GMC, glomerular mesangial cells; Mφ, macrophages; RPTC, renal proximal tubular cells.