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. 2020 Jun 3;14:24. doi: 10.3389/fncir.2020.00024

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Copyright © 2020 Luyben, Rai, Li, Georgiou, Avila, Zhen, Collingridge, Tominaga and Okamoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spatial-temporal mapping of the PAC-induced enhancement of DG depolarization. (A) Representative time-lapse images of the VSD fluorescence change (depicted in pseudocolor scale) after tetanus, collected either without (−Light; upper row) or with photostimulation to activate PAC (+Light; lower row). (B) Left and middle: pseudo-colored 3D graph of the averaged peak VSD fluorescence change in the hippocampal DG region before (Baseline) and after tetanic stimulation (+Tetanus). The 3D fluorescence images were calculated as the ratio of the fluorescence changes before and after tetanus. Right: fluorescence profiles across the lines in the 3D fluorescence distribution (white line of left and middle) fitted with a parabola. Black, before tetanic stimulation (Baseline); grey, after tetanic stimulation without photostimulation to activate PAC (+Tet/−Light); magenta, after tetanic stimulation with the photostimulation (+Tet/+Light). The same analysis shown in panel (B) which was performed without PAC activation (−Light; n = 56 images/7 slices/2 mice), was repeated in panel (C) with PAC (+Light; n = 64 images/8 slices/2 mice) activation, respectively.