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. 2020 Jun 3;11:535. doi: 10.3389/fphys.2020.00535

FIGURE 1.

FIGURE 1

Deubiquinating enzymes in the regulation of mitophagy. Dotted lines with (?) indicate a potential functional interaction, which is yet to be demonstrated. USP8 positively regulates Parkin mitochondrial recruitment and mitophagy, whereas USP15, ATXN3, and USP30 negatively impact Parkin activity. Parkin has in turn a negative feedback loop on USP30. USP14 can tune the ubiquitin proteasome system (UPS) as well as autophagy. UCH-L1 and USP24 negatively influences autophagic membrane formation. It is yet to be demonstrated whether USP14 stability can be regulated by autophagy in a negative feedback loop (?), and whether USP14 can impact USP30 stability (?). Green arrows indicate positive impact while blunt lines indicate negative / antagonizing feedback.