TABLE 1.

Deubiquitinase enzymes and Parkinson’s disease.

Name	Key features	Link to PD
USP8	Interacts with endosomal growth factor and regulates endodomal trafficking (Mizuno et al., 2005; Row et al., 2006).	Regulates Parkin activation (Durcan et al., 2014). Inhibition or downregulation protects against PD phenotypes in Drosophila model (Alexopoulou et al., 2016; von Stockum et al., 2019).
USP14	Inhibits proteasome and autophagy (Lee et al., 2010; Kim et al., 2018)	Inhibition leads to enhanced mitophagy and protect against PD phenotype in Drosophila models (Chakraborty et al., 2018).
Ataxin-3	Directly interacts with Parkin and influence the ubiquitination (Durcan and Fon, 2011; Durcan et al., 2011)	Might explain some of the PD related phenotypes in Machado–Joseph disease (Durcan et al., 2012).
USP30	Inhibits mitophagy by antagonizing Parkin (Bingol et al., 2014)	Knockdown protects against PD phenotype in Drosophila model (Bingol et al., 2014).
USP15	Inhibits mitophagy by antagonizing Parkin (Cornelissen et al., 2014).	Downregulation protects against PD phenotype in Parkin RNAi Drosophila model (Cornelissen et al., 2018).
UCH-L1	Regulates chaperon mediated autophagy and proteasome activity (Kabuta et al., 2008)	Mutant form of the protein protects against PD progression in MPTP induced mice model (Carmine Belin et al., 2007; Xilouri et al., 2012).
USP9X	Involved in cancer and Autoimmune disorders. Reversely correlated to mon-ubiquitinated α-Synuclein levels (Rott et al., 2011)	Yet to be identified.
USP24	Negative regulator of autophagy (Thayer et al., 2020)	Regulates neurite growth in dopaminergic cells (Li et al., 2006).