Table I.
Patient characteristics and measurements of haemoglobin, ferritin, CRP and O2 affinity. Data are mean ± SD (n). All control data came from patients whose samples were already analysed for a full blood count and had shown normal red cell indices and normal Hb variants by high performance liquid chromatography (HPLC). No extra samples were taken. Statistical analyses (P values) were derived from a standard Student’s t‐test and differences were considered significant at *P < 0·05). ns = not significant. na = not available.
| Control | COVID‐19 | P | |
|---|---|---|---|
| Age | 50·8 ± 10·3 (11) | 58·6 ± 16·3 (14) | ns (0·18) |
| Sex (male:female) | 5 (45%):6 (55%) | 7 (50%):7 (50%) | – |
| Total Hb (g/l) | 143 ± 11 (11) | 93 ± 23 (14) | *(<0·0001) |
| HbA2 (%) | 2·9 ± 0·1 (5) | 2·8 ± 0·3 (14) | ns (0·22) |
| PCV | 0·43 (11) | 0·29 ± 0·06 (14) | *(<0·0001) |
| Ferritin (µg/l) | na | 1,208 ± 1,328 (13) | – |
| CRP (mg/l) | 9 ± 10 (4) | 155 ± 125 (12) | * (<0·02) |
| O2 affinity P50 (mm Hg) | 28·5 ± 1·8 (11) | 29·0 ± 2·3 (14) | ns (0·40) |
| O2 affinity Hill Slope (x10−2) | 2·75 ± 0·15 (11) | 2·72 ± 0·09 (14) | ns (0·53) |