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. 2020 Jun 3;11:1125. doi: 10.3389/fimmu.2020.01125

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Copyright © 2020 Yan, Zhou, Guo, Zhou and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CGA-originated microbiota prevented intestinal morphology damage and barrier dysfunction caused by indomethacin. (A) Body weight changes after the mice were gavaged with indomethacin; (B) intestinal length; (C) Concentration of FITC-dextran in serum; (D) HE staining of colon morphology (200×), The morphology changes were marked with black arrows; Occludin (E) and claudin-1 (F) expression in colon by immunofluorescence assay (Red, tight junction proteins; Blue, DAPI). Values are expressed as mean ± SEM, n = 4. ^*P < 0.05; ^**P < 0.01.