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Schematic showing the molecular pathways associated with PDGF. PDGF activation gives rise to an increase in cell proliferation, migration, and angiogenesis through AkT, MAPK, and calcium pathways for example. PDGF is essential for efficient wound repair and minimization of potential scar tissue. Commercial product REGRANEX® utilizes recombinant human PDGF for the treatment of diabetic foot ulcers.
