Table 1.

Therapeutic potential of various electrospun polymers including therapy loaded nanofibers and tissue engineering options.

Electrospun devices	Electrospun polymers	Incorporated therapeutics	Therapeutic outcomes	References
Polymers	Recombinant Human Collagen, Chitosan and PEO	–	This dressing resulted in elevated levels of collagen III in vivo 14 days post-surgery in normal male SD rats compared to control groups, which is indicative of less scar tissue formation.	Deng et al., 2018
	Collagen Type I and PCL	-	Significantly reduced the area of scar tissue formation in back skin wounds of Sprague-Dawley rat compared to controls as determined via H&E staining.	Bonvallet et al., 2014
	Silk fibroin/gelatin	-	This dressing inhibited scar tissue formation in vivo via stimulating wound closure (p < 0.05), enhancing angiogenesis, and successfully refining collagen organization.	Shan et al., 2015
	Silk fibroin/PEO	-	This dressing stimulated rapid collagen production with a similar architecture to normal skin.	Ju et al., 2016
Polymers + therapeutic agents	Collagen (Col, mimicking protein), PCL	Bioactive glass nanoparticles	This dressing delivered bioglass nanoparticles resulting in enhanced endothelial cell attachment and proliferation in vitro. This translated to well organized collagen deposition and skin appendages in vivo compared to controls without nanoparticles in specific pathogen-free male Sprague-Dawley rats.	Gao et al., 2017
	PELA and PEG	pbFGF and PEI	This dressing after 4 weeks resulted in fully differentiated epidemic cells, closely arranged basal cells and elevated occurrences of hair and sebum, consistent with the epithelial structure of normal skin.	Yang et al., 2012
	Poly(ε-caprolactone) (PCL)/gelatin	TGF-β1 inhibitor (SB-525334)	This dressing released PGT to effectively inhibit fibroblast proliferation in vitro and this translated to the successful prevention of hypertrophic scar formation in vivo in a full-thickness wound model on the ear of female New Zealand white rabbits.	Wang et al., 2017
Polymers + cells	Recombinant Human Tropoelastin	Adipose derived stem cells (ADSC)	This dressing significantly improved wound closure and enhanced epithelial thickness in vivo in a murine excisional wound model compared to controls. It is hypothesized that the device could persist within the skin after healing and improve the overall tensile strength of the resulting scar tissue.	Machula et al., 2014
	Collagen and PCL	Keratinocytes and Fibroblasts	This layered dressing becoming unrecognizable after Day 21 post-implantation, indicative of high grafting efficiency.	Mahjour et al., 2015
	PLGA and Collagen	Bone marrow-derived MSCs (BM-MSCs)	This dressing resulted in faster wound closure times in vivo in full-thickness wound models in rats, with wounds closing 8 days earlier than controls.	Ma et al., 2011