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. 2020 Jun 3;13:81. doi: 10.3389/fnmol.2020.00081

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Copyright © 2020 Li, Ma, Chen, Hu, Li, Zhang, Su, Woodgett, Li and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tideglusib administration exerts neuroprotection against MPTP lesions. (A) A graphic of the experimental procedure is shown. (B) Immunohistochemical staining of TH (left panel), Nissl (middle panel) on the midbrain sections and TH staining on striatal sections (right panel) from saline- and MPTP-injected control and mice with gradient dosages of Tideglusib (50 mg/kg, 200 mg/kg, and 500 mg/kg). Scale bar: 100 μm (Midbrain), 500 μm (Striatum). n = 6–8 per group. (C–E) The bar graph shows the cell counts of TH-positive neurons of the whole SNpc (C), Nissl-positive cells of the whole SNpc (D), and measured IOD of striatal TH immunostaining (E). The data shows the mean ± SEM (n = 6–8 per group). ***p < 0.001 vs. saline-treated mice with vehicle administration. ^#p < 0.05, ^##p < 0.01 vs. MPTP mice with vehicle administration as indicated.