TABLE 5.
Comparison of MRI assessments between EAHE and placebo groups.
|
EAHE group (n = 20) |
Placebo group (n = 21) |
||||
| Variables | Value | Intragroup p-value | Value | Intragroup p-value | Intergroup p-value |
| Total fibers | |||||
| Baseline | 43523 ± 8327.67 | – | 41463.43 ± 8868.05 | – | 0.44 |
| Week 49 | 40085.21 ± 9124.5 | 0.001* | 38512.2 ± 11643.18 | 0.008* | 0.715 |
| D.ARC.FA | |||||
| Baseline | 0.45 ± 0.03 | – | 0.43 ± 0.03 | – | 0.05 |
| Week 49 | 0.45 ± 0.03 | 0.421 | 0.43 ± 0.04 | 0.205 | 0.148 |
| N.ARC.FA | |||||
| Baseline | 0.45 ± 0.03 | – | 0.45 ± 0.03 | – | 0.86 |
| Week 49 | 0.46 ± 0.02 | 0.144 | 0.46 ± 0.03 | 0.469 | 0.704 |
| D.PHC.FA | |||||
| Baseline | 0.39 ± 0.02 | – | 0.4 ± 0.03 | – | |
| Week 49 | 0.4 ± 0.02 | 0.609 | 0.4 ± 0.03 | 0.756 | |
| N.PHC.FA | |||||
| Baseline | 0.38 ± 0.03 | – | 0.36 ± 0.1 | – | 0.797 |
| Week 49 | 0.4 ± 0.03 | 0.266 | 0.38 ± 0.03 | 0.861 | 0.272 |
| D.IFOF.FA | |||||
| Baseline | 0.47 ± 0.02 | – | 0.44 ± 0.03 | – | 0.024* |
| Week 49 | 0.47 ± 0.02 | 0.879 | 0.44 ± 0.05 | 0.513 | 0.014* |
| N.IFOF.FA | |||||
| Baseline | 0.46 ± 0.03 | – | 0.43 ± 0.03 | – | 0.011* |
| Week 49 | 0.46 ± 0.03 | 0.276 | 0.43 ± 0.04 | 0.095 | 0.006* |
| D.UNC.FA | |||||
| Baseline | 0.41 ± 0.03 | – | 0.4 ± 0.03 | – | 0.704 |
| Week 49 | 0.4 ± 0.04 | 0.463 | 0.4 ± 0.04 | 0.828 | 0.483 |
| N.UNC.FA | |||||
| Baseline | 0.4 ± 0.03 | – | 0.4 ± 0.03 | – | 0.955 |
| Week 49 | 0.4 ± 0.03 | 0.421 | 0.4 ± 0.03 | 0.962 | 0.493 |
| D.ARC.ADC | |||||
| Baseline | 103.63 ± 6.59 | – | 106.18 ± 7.52 | – | 0.233 |
| Week 49 | 104.29 ± 8.84 | 0.711 | 109.02 ± 10.63 | 0.033* | 0.105 |
| N.ARC.ADC | |||||
| Baseline | 103.44 ± 8.65 | – | 106.66 ± 8.8 | – | 0.101 |
| Week 49 | 103.85 ± 11.09 | 0.372 | 106.56 ± 10.44 | 0.365 | 0.112 |
| D.PHC.ADC | |||||
| Baseline | 125.51 ± 9.66 | – | 127.98 ± 12.15 | – | 0.32 |
| Week 49 | 123.12 ± 7.68 | 0.03* | 123.82 ± 7.82 | 0.446 | 0.8 |
| N.PHC.ADC | |||||
| Baseline | 126.43 ± 8.8 | – | 116.56 ± 32.15 | – | 0.406 |
| Week 49 | 120.39 ± 3.74 | 0.05 | 124.43 ± 7.6 | 0.6 | 0.097 |
| D.IFOF.ADC | |||||
| Baseline | 116.76 ± 7.87 | – | 121.56 ± 7.97 | – | 0.17 |
| Week 49 | 118.02 ± 7.72 | 0.36 | 121.82 ± 9.75 | 0.748 | 0.226 |
| N.IFOF.ADC | |||||
| Baseline | 117.71 ± 7.16 | – | 122.23 ± 9.8 | – | 0.239 |
| Week 49 | 118.08 ± 7.23 | 0.744 | 120.33 ± 8.19 | 0.171 | 0.405 |
| D.UNC.ADC | |||||
| Baseline | 117.06 ± 3.93 | – | 119.19 ± 8.82 | – | 0.579 |
| Week 49 | 119.57 ± 7.68 | 0.469 | 119.06 ± 5.96 | 0.741 | 0.849 |
| N.UNC.ADC | |||||
| Baseline | 117.82 ± 5.57 | – | 119.48 ± 8.72 | – | 0.933 |
| Week 49 | 117.58 ± 5.89 | 0.307 | 120.05 ± 7.61 | 0.276 | 0.511 |
Values are given as mean ± SD. D = dominant; N = Non-dominant; ARC = arcuate fasciculus; PHC = parahippocampal cingulum; IFOF = inferior fronto-occipital fasciculus; UNC = uncinate fasciculus; FA = Fractional Anisotropy; ADC = apparent diffusion coefficient. *p < 0.05.