Table 2.

Hazard Ratios for All-cause mortality in the Patient Cohort^ab

Group	Patients (No.)	Hazard ratios
		Unadjusted	P value	Risk adjustedc	P value
CAC score
0-99	1134	1 (Referent)		1 (Referent)
100-399	573	1.40 (1.12-1.75)	.003	1.21 (0.95-1.55)	.12
≥400	611	2.07 (1.70-2.52)	<.001	1.59 (1.26-2.01)	<.001
Physical activity level
High	551	1 (Referent)		1 (Referent)
Moderate	1365	1.39 (1.10-1.74)	.006	1.26 (0.98-1.63)	.08
Low	402	1.68 (1.28-2.20)	<.001	1.60 (1.18-2.17)	.003
CAC score/physical activity level
0-99/high	276	1 (Referent)		1 (Referent)
0-99/moderate	679	1.19 (0.82-1.73)	.36	1.01 (0.67-1.52)	.96
0-99/low	179	1.14 (0.70-1.85)	.59	0.97 (0.57-1.64)	.90
100-399/high	136	1 (Referent)		1 (Referent)
100-399/moderate	329	1.07 (0.69-1.66)	.77	1.15 (0.71-1.87)	.58
100-399/low	108	1.37 (0.83-2.29)	.22	2.07 (1.16-3.69)	.01
≥400/high	139	1 (Referent)		1 (Referent)
≥400/moderate	357	1.91 (1.28-2.83)	.001	1.68 (1.06-2.66)	.03
≥400/low	115	2.63 (1.69-4.10)	<.001	2.35 (1.39-3.97)	.001

^aCAC = coronary artery calcium.

^bA formal test for interaction showed that the Wald P value interaction between CAC score and physical activity level was significant (P=.013 unadjusted and P=.009 risk adjusted).

^cHazard ratios adjusted for age, male sex, hypertension, dyslipidemia, smoking, diabetes, and family history of premature coronary artery disease, lipid-lowering medication use, and blood pressure medication use.