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. 2020 Mar 17;8(6):e1200. doi: 10.1002/mgg3.1200

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© 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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PPI network, most significant module of DEGs and Interaction network of the hub genes. (a) PPI network of DEGs was constructed in Cytoscape, red nodes represents upregulated genes, and blue nodes represents downregulated genes. (b–d) There modules were obtained from PPI network using MCODE plug‐in in Cytoscape. (e) Hub genes and their coexpression genes were analyzed by cBioPortal. Nodes with bold black outline mean hub genes. Nodes with thin black outline the coexpression genes. DEGs, differentially expressed genes; MCODE, molecular complex detection; PPI, protein–protein interaction