TABLE 3.
Functional roles of 12 key genes with degree ≥10
| Gene symbol | Full name | Function |
|---|---|---|
| ECT2 | Epithelial Cell Transforming 2 | ECT2 encodes guanine nucleotide exchange factor, and drives the proliferation and invasion of breast cancer, lung cancer, and gastric cancer. |
| WDHD1 | WD Repeat And HMG‐Box DNA Binding Protein 1 | WDHD1 is the replication initiation factor and involved in the mechanisms of the cancer promotion of E7 genes by evading mitotic checkpoints and inducing polyploid formation |
| TYMS | Thymidylate Synthetase | TYMS encodes thymidine synthase (TS), an important rate‐limiting enzyme that catalyzes the synthesis of pyrimidines, and also a target of fluorouracil medicines. |
| FANCI | FA Complementation Group I | FANCI and FANCD form heterodimers, and participate in DNA repairing and maintain the stability of chromosomes |
| CXCL8 | C‐X‐C Motif Chemokine Ligand 8 | CXCL8 is a chemotactic factor and induces inflammatory responses, neovascularization, and regulates immune responses |
| MCM2 | Minichromosome Maintenance Complex Component 2 | Participate in the initiation and elongation of DNA replication, form a cocktail of antibodies with TOP2A for cervical lesions |
| HELLS | Helicase, Lymphoid Specific | This gene encodes a lymphoid‐specific helicase. Participates in DNA replication, transcription and repair, and plays a role in cell proliferation |
| DTL | Denticleless E3 Ubiquitin Protein Ligase Homolog | DTL is E3 ubiquitin ligase. When DNA is damaged, DTL ubiquitin degrades relevant enzymes to prevent DNA duplication and maintain the stability of genome |
| CEP55 | Centrosomal Protein 55 | CEP55 is a member of the coiled‐coil protein family. Its main function is anchoring the microtubule polymerization‐related proteins, involving in spindle formation, then regulating cell proliferation. |
| CDK1 | Cyclin‐Dependent Kinase 1 | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression |
| AURKA | Aurora kinase A | AURKA promotes tumor cell proliferation and invasion, which is related to the resistance of chemotherapy and radiosensitivity |
| TOP2A | DNA Topoisomerase II Alpha | TOP2A can control and alter the topologic states of DNA and can be used to identify advanced cervical lesions |