Table 2.
Peripheral Organ Vector Genome Biodistribution
| Rabbit No. | Treatment | vg Detected/Organ | Rabbit No. | Treatment | vg Detected/Organ |
|---|---|---|---|---|---|
| 25 | saline | − | 46 | IDUA (1e9 vg) | − |
| 29 | saline | ++/heart | 49 | IDUA (1e9 vg) | − |
| 33 | saline | − | 53 | IDUA (1e9 vg) | +/kidney |
| 37 | saline | − | 27 | IDUA (1e10 vg) | − |
| 41 | saline | − | 31 | IDUA (1e10 vg) | − |
| 45 | saline | − | 35 | IDUA (1e10 vg) | − |
| 26 | IDUA (1e9 vg) | − | 39 | IDUA (1e10 vg) | − |
| 30 | IDUA (1e9 vg) | − | 43 | IDUA (1e10 vg) | − |
| 34 | IDUA (1e9 vg) | − | 47 | IDUA (1e10 vg) | − |
| 38 | IDUA (1e9 vg) | − | 51 | IDUA (1e10 vg) | − |
| 42 | IDUA (1e9 vg) | − | 54 | IDUA (1e10 vg) | +/kidney |
Organs assayed included non-injected cornea, spleen, liver, heart, and kidney. −, not detected in any organ; +, <2e6 vg/μg host DNA; ++, <1e9 vg/μg host DNA.