Figure 3.

PTPσ Deletion Induces Abnormal Organization of Synaptic Structures

(A) Representative electron micrographs of hippocampal neurons cultured from PTPσ^f/f mice infected with lentiviruses expressing ΔCre (control) or Cre.

(B and C) PTPσ deletion increases length of synaptic membranes. Cumulative distribution of the lengths of AZ (B) and PSD (C) for the indicated genotypes. Data are means ± SEMs (n denotes the number of analyzed neurons; ΔCre, 100 and Cre, 88; ^∗p < 0.05; ^∗∗∗p < 0.001; Mann-Whitney U test).

(D) Total numbers of vesicles per bouton in control and PTPσ-deficient synapses. Data are means ± SEMs (n denotes the number of analyzed neurons; ΔCre, 100 and Cre, 88).