Table 1.
Some benzimidazole-based drugs along with their trade names, classified according to their status by the World Health Organisation (WHO), biological target for the initial therapeutic indication, and cost per single dose.
| Mebendazole | Albendazole | Triclabendazole | Omeprazole | Bendamustine | |
|---|---|---|---|---|---|
| Trade Name | Vermox® | Albenza® | Egaten® | Losec® | Treanda® |
| WHO Ess. Med. | Yes | Yes | Yes | Yes | Yes |
| Target | Parasitic worms | Parasitic worms | Parasitic worms | PPI | Leukemia, lymphoma, myeloma [7]. |
| Anticancer Potential | CBCIs, kinase inh [8]. (colon, lung, adrenocortical, breast cancer) [9] | Modulation of oxidative stress, induction of DNA damage [10]. (colorectal, hepatoc. carcinoma) | Abcg2 inh [11]. | FASN thioesterase activity inh. [12], colon cancer [13]. | |
| Cost (USD)/Dose | 0.04–0.004 | 0.06 | 0.01–0.06 | 0.06 |