Table 3.

Temperature (B-factor) and occupancy factor values in (Ų) for non-hydrogen atoms of methyl N-[5-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate (PDB: GIG) (left panel) obtained from its X-ray cocrystal with VEGFR-2 (PDB: 2OH4) and methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo [4,3-b]pyridazin-3-yl]sulfanyl}-1H-benzimidazol-2-yl)carbamate (PDB: 63B, 2 entries) (right panel) co-crystalized with Hepatocyte GFR (PDB: 5HNI). The 2D structures and atoms numbering can be viewed from Figure 8.

Methyl N-[5-[4-[[2-fluoro-5-(trifluoromethyl)phenyl] carbamoylamino] phenoxy]-1H-benzimidazol-2-yl] carbamate		Methyl (6-{[6-(4-fluorophenyl)[1,2,4] triazolo [4,3-b]pyridazin-3-yl]sulfanyl}-1H-benzimidazol-2-yl)carbamate
Atom Number	B-factor	Atom Number	B-factor
C36	50.45	F	38.29
O35	46.86	F	37.08
F3	46.26	O2	36.90
F4	46.20	O1	36.83
F11	44.51	O1	36.41
F1	44.16	O2	36.07
C2	43.44	C17	35.62
O34	43.38	C17	35.19
C33	43.01	C20	34.98
C9	42.46	N4	34.80
C10	42.27	C14	34.78
C8	41.43	C14	34.75
C5	41.36	C15	34.58
N32	41.36	C2	34.18
C6	41.35	C19	34.13
C7	41.10	C19	33.95
N26	39.89	N3	33.94
N12	39.74	C10	33.84
C21	39.71	N1	33.60
C24	39.67	C20	33.59
C17	39.63	C11	33.40
C20	39.44	N2	33.36
C19	39.30	C7	33.22
C13	39.17	C1	33.16
C16	39.11	C15	33.13
C23	38.72	C3	33.11
O22	38.65	C4	33.08
C31	38.63	C6	32.89
C18	38.62	C10	32.88
C30	38.56	C7	31.76
N15	38.31	C11	31.73
C25	38.15	N4	31.47
C27	37.52	C4	30.88
N28	36.65	N3	30.76
O14	36.58	C2	30.68
C29	36.28	N7	30.51
		C1	30.36
		S1	30.26
		N1	30.21
		N2	30.06
		N7	29.69
		C6	29.60
		C3	29.41
		S1	28.48
		C5	27.38
		C8	26.47
		C5	26.31
		C18	25.76
		C8	24.61
		N5	24.42
		C9	24.41
		C12	24.24
		C18	24.07
		C9	23.78
		N6	23.70
		C16	23.66
		N5	23.54
		C12	23.01
		N6	22.99
		C13	22.94
		C13	22.89
		C16	22.54
Average	40.89		30.55
Occ. Factor	1		1