Table 2.

GSEA using the 61 genes upregulated in thymic bona fide GZL compared with cHL and PMBCL

Gene set name	No. of genes in gene set (K)	Description	Genes in overlap (k)	k/K	P	FDR q value
REACTOME_METALLOTHIONEINS_BIND_METALS	11	Metallothioneins bind metals	MT2A, MT1F, MT1G, MTIH, MT1M	0.4545	4.1E-12	9.23E-9
REACTOME_RESPONSE_TO_METAL_IONS	14	Response to metal ions	MT2A, MT1F, MT1G, MTIH, MT1M	0.3571	1.77E-11	1.99E-8
HALLMARK_TNFA_SIGNALING_VIA_NFKB	200	Genes regulated by NF-κB in response to TNF	IL1B, LIF, PTGS2, CXCL3, FOS, DUSP1, NR4A1, FOSB, NR4A2	0.0450	3.5E-11	2.62E-8
REACTOME_INTERLEUKIN_10_SIGNALING	46	IL-10 signaling	IL1B, LIF, PTGS2, CXCL8, IL1RN	0.1087	1.17E-8	6.56E-6
NABA_MATRISOME	1026	Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins	IL1B, LIF, CXCL3, CXCL8, IL1RN, THPO, HPX, MMP13, ADAMTS18, HYAL4, ASPN, EYS12	0.0117	7.15E-8	3.22E-5
PID_AP1_PATHWAY	70	AP-1 transcription factor network	FOS, FOSB, MT2A, DUSP1, CXCL8	0.0714	1,00E-07	3.75E-5
NABA_MATRISOME_ASSOCIATED	751	Ensemble of genes encoding ECM-associated proteins including ECM-affiliated proteins, ECM regulators and secreted factors	IL1B, LIF, CXCL3, CXCL8, IL1RN, THPO, HPX, MMP13, ADAMTS18, HYAL4	0.0133	3.07E-7	9.87E-5
HALLMARK_INFLAMMATORY_RESPONSE	200	Genes defining inflammatory response	IL1B, LIF, CXCL8, MET, KCNJ2, FFAR2	0.0300	8.53E-7	2.4E-4
REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING	111	IL-4 and IL-13 signaling	IL1B, LIF, PTGS2, FOS, CXCL8	0.0450	1.01E-6	2.52E-4
REACTOME_CELLULAR_RESPONSES_TO_EXTERNAL_STIMULI	535	Cellular responses to external stimuli	MT2A, MT1F, MT1G, MTIH, MT1M, FOS, CXCL8, HSPA6	0.0150	2.22E-6	4.99E-4

GSEA was performed by using the Hallmark and C2 canonical pathway databases. FDR, false discovery rate.