Table 1.
Distribution of compounds per motility phenotype in S. mansoni schistosomulae adult stages. Three-day-old schistosomulae were incubated with 10 μM compound for 24 h and motility recorded one and five days after compound application. Adult male and female parasites were exposed to 10 μM of each compound for 24 h and motility was recorded after compound incubation and seven days later. Numbers in brackets represent percentage of total selected compounds. * Total compounds for both sexes and reading timepoints. **N.S. indicates no significant change in motility compared to control animals.
|
Schistosomulae |
Adults |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 5 | Day 1 & 5 |
Male Day 1 |
Female Day 1 |
Both Day 1 |
Male Day 7 |
Female Day 7 |
Both Day 7 |
Total Adults* |
|
| Hypermotility | 36 (51.4%) | 13 (18.6%) | 11 (15.7%) | 17 (23.9%) | 18 (25.4%) | 10 (14.1%) | 3 (4.8%) | 3 (4.8%) | 0 (0%) | 1 (1.4%) |
| Hypomotility | 15 (21.4%) | 36 (51.4%) | 11 (15.7%) | 8 (11.3%) | 9 (12.7%) | 4 (5.6%) | 29 (46%) | 37 (58.7%) | 20 (31.7%) | 2 (2.8%) |
| N.S.** | 19 (27.1%) | 21 (30%) | 5 (7.1%) | 46 (64.8%) | 44 (62%) | 34 (47.9%) | 31 (49.2%) | 23 (36.5%) | 11 (17.5%) | 9 (12.7%) |