Table 2.

Compounds with reported activity against schistosomes in vitro and/or in vivo

Compound	Name	Class	Reference(s)
	(R)-PZQ	anthelmintica	(Olliaro et al., 2014; Kovac et al., 2017; Vale et al., 2017)
	(S)-PZQ	anthelmintica
	Arecoline	anthelminticb	(Mellin et al., 1983; Day et al., 1996; MacDonald et al., 2014; El-Sakkary et al., 2018)
	Chlorpromazine	antipsychotic	(El-Sakkary et al., 2018; Weeks et al., 2018)
	Trifluoperazine	antidepressant	Panic et al. (2015b)
	Paroxetine	antidepressant	(Neves et al., 2016; Weeks et al., 2018)
	Mefloquine	antiplasmodial	Van Nassauw et al. (2008)
	Flunarizine	antihypertensive	Panic et al. (2015b)

^aDiscovered as a racemate from a discontinued antipsychotic drug discovery programme.

^bAn old intestinal purgative used as a canine anthelmintic and diagnostic tool for echinococcosis.