Table 3.

PSMD and mean MD and their associations with cognitive scores. Standardized beta-coefficients and p-values are shown.

	β-coefficients PSMD (95% CI)	PSMD p-value	PSMD Adj R2	β coefficients mean MD (95% CI)	Mean MD p-value	Mean MD Adj R2
Memory z-score	−0.303 (−0.644 to 0.038)	0.080	0.282	−0.128 (−0.476 to 0.219)	0.455	0.210
MMSE	−0.313 (−0.704 to 0.077)	0.111	0.110	−0.202 (−0.574 to 0.170)	0.276	0.067
Executive Function z-score	−0.206 (−0.692 to 0.149)	0.197	−0.032	−0.205 (−0.601 to 0.190)	0.296	−0.053
Processing Speed z-score	−0.627 (−0.941–0.314)	<0.001	0.426	−0.480 (−0.780 to −0.162)	0.004	0.318
log(WMH) volume	0.743 (0.482 to 1.004)	<0.001	0.587	0.722 (0.484 to 0.960)	<0.001	0.614
Number of CMBs	0.086 (−0.332 to 0.503)	0.677	−0.056	0.227 (−0.159 to 0.613)	0.239	−0.014
Cortical thickness	−0.197 (−0.621 to 0.226)	0.348	0.127	−0.047 (−0.446 to 0.351)	0.810	0.099
CAA SVD score	0.681 (0.241 to 1.121)	0.004	0.349	0.684 (0.338 to 1.030)	<0.001	0.459