Table 2.
Screening parameters for eligible patients.
| # | Parameter | Required level |
|---|---|---|
| A. Bone Marrow Function | ||
| i. | Absolute neutrophil count (ANC) | >1.5 × 109/L |
| ii. | Platelet count | ≥100 × 109/L |
| iii. | Haemoglobin | ≥10.0 g/dl |
| B. Hepatic Function | ||
| i. | Aspartate transaminase (AST) | ≤3x ULN |
| ii. | Alanine transaminase (ALT) | ≤3x ULN |
| iii. | Bilirubin | ≤1.5x ULN (<2 x ULN if hyperbilirubinemia is due to Gilbert's syndrome) |
| C. Renal Function | ||
| i. | Estimated glomerular filtration rate (eGFR) | ≥45 ml/min using the Cockcroft-Gault |
Abbreviations: dl – decilitre; g – gram; L – Litre; ml – milliliter; min – minute; ULN – Upper Limit of Normal.