Table 3.

Prediction of functional effects of SNPs on protein structure.

SNP	Substitution	SIFT		Polyphen		Provean		SNAP-2
		Prediction	Score	Prediction	Score	Prediction	Score	Prediction	Score	Accuracy
rs12329760	V197M	Deleterious	0.006	Probably damaging	0.999	Neutral	−1.891	Effect	49	71%
rs75603675	G8V	Tolerated	0.201	Benign	0.386	Neutral	0.401	Neutral	−16	57%
rs75603675	G8D	Not found		Possibly damaging	0.815	Neutral	0.222	Neutral	−8	53%