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. 2020 Jun 7;26(21):2702–2714. doi: 10.3748/wjg.v26.i21.2702

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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A model of the differential transcription of REG genes in colon crypt cells in Crohn’s disease and ulcerative colitis. Increased interleukin-22 induced transcriptions of REG1/3 in Crohn’s disease (orange solid arrows) are relatively attenuated in ulcerative colitis (orange dotted arrows), leading to CDX2-activated REG transcriptions in ulcerative colitis (black solid arrows), but not in Crohn’s disease (black dotted arrows). IL: Interleukin; TGF: Transforming growth factor; TLR: Toll-like receptor.