Table 3.
Results of exposure to chemotherapy in xenotransplanted zebrafish embryos
|
Mean relative tumor area |
Mean difference |
95%CI |
P value |
|||||||||||||
| Con-trol group | FOLF-OXIRI | GEMO-X | GEM/ nab-P | GEM | k vs FOLF-OXIRI | k vs GEMO-X | k vs GEM/ nab-P | k vs Gemci-tabine | k vs FOLF-OXIRI | k vs GEMO-X | k vs GEM/ nab-P | k vs Gemci-tabine | k vs FOLF-OXIRI | k vs GEMO-X | k vs GEM/ nab-P | k vs Gemci-tabine |
| 3.026 | 0.790 | 1.243 | 0.988 | 1.213 | 2.236 | 1.784 | 2.038 | 1.813 | 0.286 to 4.187 | -0.167 to 3.734 | -0.047 to 4.123 | -0.198 to 3.823 | 0.020 | 0.081 | 0.057 | 0.087 |
| 1.964 | 0.755 | 1.188 | 0.529 | 1.674 | 1.209 | 0.776 | 1.435 | 0.290 | -0.016 to 2.434 | -0.522 to 2.073 | 0.099 to 2.771 | -0.978 to 1.558 | 0.054 | 0.361 | 0.032 | 0.936 |
| 1.699 | 0.524 | 1.599 | 1.238 | 0.706 | 1.175 | 0.100 | 0.461 | 0.993 | -0.026 to 2.376 | -1.348 to 1.548 | -0.645 to 1.567 | -0.113 to 2.099 | 0.057 | 0.999 | 0.659 | 0.088 |
| 1.604 | 0.951 | 1.990 | 1.767 | 1.013 | 0.653 | -0.385 | -0.163 | 0.592 | -0.452 to 1.759 | -1.551 to 0.780 | -1.269 to 0.942 | -0.724 to 1.907 | 0.381 | 0.817 | 0.987 | 0.616 |
| 2.357 | 2.260 | 1.689 | 1.566 | 1.263 | 0.097 | 0.668 | 0.792 | 1.094 | -2.112 to 0.261 | -1.363 to 2.700 | -0.679 to 2.262 | -0.479 to 2.668 | > 0.990 | 0.817 | 0.458 | 0.244 |
| 2.098 | 0.714 | 1.423 | 1.130 | 1.672 | 1.384 | 0.674 | 0.968 | 0.426 | -2.112 to 0.261 | -0.826 to 2.175 | -0.411 to 2.346 | -1.075 to 1.926 | 0.034 | 0.610 | 0.236 | 0.879 |
| 2.170 | 1.663 | 1.746 | 1.205 | 0.965 | 0.507 | 0.424 | 0.966 | 1.205 | -2.112 to 0.261 | -0.760 to 1.607 | -0.478 to 2.409 | 0.022 to 2.388 | 0.560 | 0.770 | 0.270 | 0.040 |
| 1.224 | 0.489 | 1.802 | 1.189 | 1.221 | 0.735 | -0.578 | 0.035 | 0.003 | -2.112 to 0.261 | -2.130 to 0.975 | -1.311 to 1.382 | -1.549 to 1.556 | 0.730 | 0.750 | > 0.990 | > 0.990 |
| 1.606 | 0.710 | 0.423 | 0.606 | 0.945 | 0.896 | 1.183 | 1.000 | 0.662 | -2.112 to 0.261 | -0.383 to 2.748 | 0.083 to 1.918 | -0.417 to 1.740 | 0.057 | 0.183 | 0.029 | 0.342 |
| 1.046 | 0.575 | 1.037 | 0.468 | 0.514 | 0.471 | 0.009 | 0.579 | 0.533 | -2.112 to 0.261 | -1.094 to 1.113 | -0.557 to 1.714 | -0.586 to 1.650 | 0.643 | > 0.990 | 0.506 | 0.563 |
| 2.669 | 1.203 | 1.207 | 1.428 | 1.371 | 1.466 | 1.462 | 1.241 | 1.298 | -2.112 to 0.261 | -1.407 to 4.331 | -1.326 to 3.807 | -1.268 to 3.864 | 0.338 | 0.492 | 0.537 | 0.499 |
| 1.371 | 0.852 | 0.705 | 1.383 | 1.077 | 0.520 | 0.666 | -0.012 | 0.294 | -0.667 to 1.706 | -0.775 to 2.107 | -1.452 to 1.429 | -0.774 to 1.363 | 0.627 | 0.584 | > 0.990 | 0.888 |
| 1.648 | 0.8481 | 0.8028 | 1.174 | 1.273 | 0.7996 | 0.8449 | 0.4737 | 0.3748 | 0.019 to 1.580 | -0.030 to 1.720 | -0.3717 to 1.319 | -0.471 to 1.220 | 0.043 | 0.061 | 0.433 | 0.632 |
| 1.275 | 1.704 | 0.888 | 2.157 | 1.683 | -0429 | 0.387 | -0.882 | -0.408 | -1.975 to 1.117 | -0.957 to 1.731 | -2.428 to 0.664 | -1.954 to 1.138 | 0.879 | 0.864 | 0.394 | 0.896 |
| 1.041 | 1.966 | 1.167 | 0.789 | 1.091 | -0.926 | -0.126 | 0.252 | -0.050 | -2.112 to 0.261 | -1.356 to 1.104 | -1.035 to 1.539 | -1.281 to 1.180 | 0.162 | > 0.990 | 0.963 | > 0.990 |
k: Control group; GEM: Gemcitabine; GEMOX: Gemcitabine + Oxaliplatin; GEM/nab-P: Gemcitabine + nab-Paclitaxel; FOLFOXIRI: 5-Fluorouracil + Folinic acid + Oxaliplatin + Irinotecan.