REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
1B07, anti-SARS-CoV-2 mAb	This paper	N/A
2F05, anti-SARS-CoV-2 mAb	This paper	N/A
2H09, anti-influenza A virus mAb	This paper	N/A
Goat anti-human ACE2 antibody	R&D	AF933; RRID: AB_355722
APC-conjugated donkey anti-goat IgG secondary antibody	Thermo Fisher	A32849; RRID: AB_2762840
CR3022, anti-SARS-CoV-2 mAb	Yuan et al., 2020	N/A
HRP-conjugated goat anti-human IgG	Thermo Fisher	62-8420; RRID: AB_2533962
MAR1-5A3, anti-Ifnar1 mAb	Leinco	I-401; RRID: AB_2491621
Virus Strains
SARS-CoV-2 (strain 2019 n-CoV/USA_WA1/2020)	CDC/BEI Resources	NR52281
AdV-hACE2-GFP	Jia et al., 2005	N/A
AdV-hACE2	Jia et al., 2005	N/A
Experimental Models: Cell Lines
Vero CCL-81	ATCC	CCL-81; RRID: CVCL_0059
Vero E6	ATCC	CRL-1586; RRID: CVCL_0574
HEK293	ATCC	CRL-1573; RRID: CVCL_0045
HEK293T	ATCC	CRL-3216; RRID: CVCL_0063
Experimental Models: Organisms/Strains
Mouse: C57BL/6J	Jackson Laboratory	Cat#000664; RRID: IMSR_JAX:000664
Mouse: BALB/c	Jackson Laboratory	Cat#000651; RRID: IMSR_JAX:000651
Mouse: DBA/2J	Jackson Laboratory	Cat#000671; RRID: IMSR_JAX:000671
Mouse: Rag1−/− C57BL/6	Jackson Laboratory	Cat#002216; RRID: IMSR_JAX:002216
Mouse: Stat1−/− C57BL/6	Jackson Laboratory	Cat#012606; RRID: IMSR_JAX:012606
AG129	Marshall BioResources	AG129
Oligonucleotides
SARS-CoV-2 N F: 5′-ATGCTGCAATCGTGCTACAA-3′	This paper	N/A
SARS-CoV-2 N R: 5′-GACTGCCGCCTCTGCTC-3′	This paper	N/A
SARS-CoV-2 N Probe: 5′-/56-FAM/TCAAGGAAC/ZEN/AACATTGCCAA/3IABkFQ/-3′	This paper	N/A
SARS-CoV-2 RNA ISH probe (S gene)	Advanced Cell Diagnostics	Cat# 4848561
Human ACE2 RNA ISH probe	Advanced Cell Diagnostics	Cat# 848151
Gapdh TaqMan Primer/Probe set	IDT	Mm.PT.39a.1
Human ACE2 TaqMan Primer/Probe set	IDT	Hs.PT.58.27645939
Ifng TaqMan Primer/Probe set	IDT	Mm.PT.58.41769240
Il6 TaqMan Primer/Probe set	IDT	Mm.PT.58.10005566
Il1b TaqMan Primer/Probe set	IDT	Mm.PT.58.41616450
Tnfa TaqMan Primer/Probe set	IDT	Mm.PT.58.12575861
Cxcl10 TaqMan Primer/Probe set	IDT	Mm.PT.58.43575827
Ccl2 TaqMan Primer/Probe set	IDT	Mm.PT.58.42151692
Ccl5 TaqMan Primer/Probe set	IDT	Mm.PT.58.43548565
Cxcl11 TaqMan Primer/Probe set	IDT	Mm.PT.58.10773148.g
Ifnb TaqMan Primer/Probe set	IDT	Mm.PT.58.30132453.g
Ifnl(2/3) TaqMan Primer/Probe set	Thermo Fisher	Mm04204156_gH
Software and Algorithms
BioRender	BioRender.com	N/A
FlowJo	FlowJo, LLC	v10
GraphPad Prism	GraphPad	v 8.2.1
Recombinant DNA
pABVec6W	Davis et al., 2019	N/A
PCR-II topo	Invitrogen	Cat# 451245