. 2020 Jun 9;323(22):2281–2289. doi: 10.1001/jama.2020.7172

Table 3. Adjusted Incidence Rate of Major Cardiovascular Disease per 1000 Person-Years of Vascular Risk Factors With and Without the Addition of Migraine With Aura (N = 27 858)^a.

Risk factor	Adjusted incidence rate (95% CI)^a		P value^c
Risk factor	With migraine with aura	Without migraine with aura^b	P value^c
Diabetes	6.92 (5.05-8.79)	4.35 (3.48-5.22)	<.001
Current smoking	5.50 (4.29-6.72)	3.46 (3.02-3.90)	<.001
Systolic blood pressure ≥160 mm Hg	4.46 (2.98-5.94)	2.80 (2.02-3.58)	.001
Total cholesterol ≥280 mg/dL	3.40 (2.55-4.24)	2.13 (1.76-2.51)	<.001
HDL cholesterol <40 mg/dL	3.22 (2.50-3.93)	2.02 (1.75-2.30)	<.001
Triglycerides ≥194 mg/dL	3.29 (2.58-4.01)	2.07 (1.81-2.33)	<.001
Family history of myocardial infarction prior to age 60 y	3.30 (2.57-4.04)	2.07 (1.80-2.35)	<.001
Body mass index ≥30	2.71 (2.11-3.32)	1.71 (1.48-1.93)	<.001

Abbreviation: HDL, high-density lipoprotein.

^{^a}

Adjusted for the vascular risk factors (dichotomous) shown in the table plus age, alcohol use, exercise, hypertensive treatment, ever use of hormones, and premenopausal status.

^{^b}

Includes women who reported migraine without aura and those who did not report migraine in the year prior to baseline.

^{^c}

P value shows the contrast of each factor without adding migraine with aura vs adding migraine with aura.

Table 3. Adjusted Incidence Rate of Major Cardiovascular Disease per 1000 Person-Years of Vascular Risk Factors With and Without the Addition of Migraine With Aura (N = 27 858)a.

Table 3. Adjusted Incidence Rate of Major Cardiovascular Disease per 1000 Person-Years of Vascular Risk Factors With and Without the Addition of Migraine With Aura (N = 27 858)^a.