Table 4. Adjusted Incidence Rate of Major Cardiovascular Disease per 1000 Person-Years for Combinations of Major Vascular Risk Factors With and Without the Addition of Migraine With Aura (N = 27 858)^a.

Risk factor combination	Adjusted rate (95% CI)a		P valuec
	With migraine with aura	Without migraine with aurab
Current smoking, total cholesterol ≥280 mg/dL, HDL cholesterol <40 mg/dL, triglycerides ≥194 mg/dL, family history of MI	15.90 (11.19-20.62)	9.99 (7.62-12.37)	<.001
Diabetes, SBP ≥160 mm Hg, total cholesterol ≥280 mg/dL, triglycerides ≥194 mg/dL, BMI ≥30	22.79 (13.64-31.95)	14.32 (9.23-19.41)	.002
Diabetes, SBP ≥160 mm Hg, total cholesterol, HDL cholesterol <40 mg/dL, triglycerides ≥194 mg/dL, BMI ≥30	28.97 (17.38-40.56)	18.20 (11.75-24.65)	.002
Diabetes, current smoking, SBP ≥160 mm Hg, HDL cholesterol <40 mg/dL, triglycerides ≥194 mg/dL, BMI ≥30	46.95 (28.71-65.18)	29.49 (19.50-39.48)	.002
Diabetes, current smoking, total cholesterol ≥280 mg/dL, HDL cholesterol <40 mg/dL, triglycerides ≥194 mg/dL, family history of MI, BMI ≥30	46.58 (30.61-62.54)	29.26 (20.81-37.70)	.001
Diabetes, current smoking, SBP ≥160 mm Hg, total cholesterol ≥280 mg/dL, HDL cholesterol <40 mg/dL, triglycerides ≥194 mg/dL, BMI ≥30	62.96 (37.13-88.80)	39.55 (25.13-53.97)	.002

Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); HDL, high-density lipoprotein; MI, myocardial infarction; SBP, systolic blood pressure.

^aAdjusted for the vascular risk factors (dichotomous) shown in the table plus age, alcohol use, exercise, hypertensive treatment, ever use of hormones, and premenopausal status.

^bIncludes women who reported migraine without aura and who reported no migraine in the year prior to baseline.

^cP value shows the contrast of the combination of vascular risk factors without adding migraine with aura vs adding migraine with aura.