Figure 2. Schematic diagram of adipogenesis in healthy and obese states.

ASCs give rise to different adipocytes. White adipocytes store energy, whereas brown and beige adipocytes are specialized for energy expenditure. Of note, transdifferentiation between beige and white adipocytes, or between brown and white adipocytes are also suggested. In addition, mature white adipocytes have the ability to dedifferentiate into multipotent ASCs. In obese state, the roles of ASCs get altered, leading to the generation of more white fat and the whitening of thermogenic brown and beige fat.