Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overview of upstream open reading frame (uORF)-mediated repression of gene expression. (A) The uORF mRNA is translated into protein by ribosomes. (B) On the other hand, uORF-mediated repression of the main ORF (mORF) occurs in polycistronic uORF+ mRNA. Translation repression of an mORF occurs by ribosome releasing after uORF translation or ribosome stalling in the uORF. Some are eliminated by RNA decay pathways like nonsense-mediated mRNA decay (NMD).
