Table 1.
Excipient composition of IR ibuprofen tablets prepared in-house. Formulations were named according to the diluent mixture used.
| MCC D | MCC G | CaHPO4 D | CaHPO4 G | Dex D | Dex G1 | Dex G2 | CaSO4 D | CaSO4 G |
|---|---|---|---|---|---|---|---|---|
| Avicel PH102 (800 mg) | Avicel PH102 (800 mg) | Avicel PH102 (400 mg) | Avicel PH102 (400 mg) | Avicel PH102 (400 mg) | Avicel PH102 (400 mg) | Avicel PH102 (460 mg) | Avicel PH102 (400 mg) | Avicel PH102 (400 mg) |
| Ibuprofen (400 mg) | Ibuprofen (400 mg) | Ibuprofen (400 mg) | Ibuprofen (400 mg) | Ibuprofen (400 mg) | Ibuprofen (400 mg) | Ibuprofen (400 mg) | Ibuprofen (400 mg) | Ibuprofen (400 mg) |
| CS (3%) | CS (5%) | CS (3%) | CS (5%) | CS (3%) | CS (5%) | CS (5%) | CS (3%) | CS (5%) |
| Mg Stearate (1%) | Mg Stearate (1%) | Mg Stearate (1%) | Mg Stearate (1%) | Mg Stearate (1%) | Mg Stearate (1%) | Mg Stearate (1%) | Mg Stearate (1%) | Mg Stearate (1%) |
| CaHPO4 (400 mg) | CaHPO4 (400 mg) | Dextrose (400 mg) | Dextrose (400 mg) | Dextrose (400 mg) | CaSO4 (400 mg) | CaSO4 (400 mg) | ||
| Starch 1500 (210 mg) | Starch 1500 (210 mg) | Starch 1500 (210 mg) | Starch 1500 (210 mg) | |||||
| Expected microclimate effect | ||||||||
| - | ↑ | ↓ | ↓↓ | ↑↑ | ||||
MCC: microcrystalline cellulose (Avicel PH102); Dex: Dextrose; CaHPO4: dicalcium phosphate dihydrate; CaSO4: calcium sulfate; D: direct compression; G: wet granulation; CS: croscarmellose sodium; (↑ and ↑↑): increased dissolution; (↓ and ↓↓): deceased dissolution; (-): no effect.