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. 2020 May 11;12(5):442. doi: 10.3390/pharmaceutics12050442

Table 1.

Advantages and disadvantages EVs and EVMs.

Advantages Disadvantages References
Natural EVs

  • Natural packing of biological materials (e.g., protein and RNAs)

  • Defined biomarkers (CD63, CD9, CD81, and Alix)

  • Low yield

  • Isolation—time consuming

  • Low/moderate loading capacity

 [1,2,29,30,32,62,64]
Engineered EVMs

  • High yield (generally 100-fold more than EVs)

  • Isolation—short time (20-fold-less than EVs)

  • High loading capacity

  • Generation of Hybrid EVMs

  • Deformation of membrane

  • Contamination of DNAs

  • Random packing of biological materials

  • No definite biomarker

 [25,28,29,32,65,66]