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. 2020 May 7;12(5):432. doi: 10.3390/pharmaceutics12050432

Table 2.

Examples of different types of therapeutic peptides delivered by mesoporous silica-based nanocarriers.

Peptide Carrier Pore Cargo Release Mechanism Cell Line(s) In Vivo Reference
Anticancer Peptides
K8-Citraconate
K8(RGD)2 		MSNs Doxorubicin Electrostatic COS7, U87 MG None [111]
TPP-K-(KLAKLAK)2- MSNs Topotecan Electrostatic/Redox cleavage KB None [112]
C-GRK2R2QR3P2Q-RGDS
C-GKGG-D(KLAKLAK)2 		MSNs Doxorubicin Redox cleavage HeLa, COS7 None [113]
(RGDWWW)2KC MSNs Doxorubicin Redox cleavage COS7, U87 MG Mice [114]
(KLAKLAK)2 MSNs Doxorubicin Enzymatic degradation
Redox cleavage		 HeLa None [115]
ε-poly-l-lysine
C9h		 MSNs C9h Enzymatic degradation
Pore release		 HeLa None [116]
RDG-Hylin a1 MSNs RDG-Hylin a1 Pore release HeLa Hep2 Mice [117]
Pepstatin A HMSNs Pepstatin A Release from cavity MCF-7 None [118]
NuBCP9 MSNs NuBCP9 Pore release HeLa, HEK293 Zebrafish [119]
NuBCP9 PAMAM@MSNs NuBCP9 Pore release upon PAMAM detachment HepG2,H292, MCF-7,HeLa Mice [120]
Immunostimulating Peptides
HGP100
TRP2		 HMSNs HGP100
TRP2		 Lipid layer disassembly
Release from cavity		 BMDCs None [121]
Antibacterial Peptides
LL37 SiO2/MSNs None/LL37 Surface adsorption vs. pore release E. coli None [122]
NZX MSNs NZX Pore release Mycobacterium tuberculosis Mice [123]
Melittin MSNs@
MagMSNs		 Melittin
Ofloxacin		 Pore release upon hyperthermia triggering Pseudomonas aeruginosa Mice [124]
Hormones and Growth Factors
Insulin MSNs cAMP Glucose-mediated displacement RIN-5F None [125]
MSNs Insulin Glucose-sensitive polymer shell None None [126]
MSNs Insulin Pore release Caco-2 None [127]
Osteostatin MSNs Osteostatin Pore release MC3T3-E1 Rabbit [128,129,130]
OGP MSNs
MS-HANs		 OGP Pore release None None [131]
BMP-2 MSNs Surface None BMSCs Rat [132]

For an illustrative revision of the coupling protocols employed for linking peptides onto nanocarriers, please check Reference [133]. Abbreviations: BMDCs: murine bone-marrow-derived dendritic cells; BMP-2: bone morphogenetic protein 2; BMSCs: rat bone mesenchymal stem cells; cAMP: cyclic adenosine monophosphate; MagMSNs: SPION@MSNs core–shell nanoparticles; MS-HANs: mesoporous silica–hydroxyapatite nanoparticles; OGP: osteogenic growth peptide; PAMAM: polyamidoamine dendrimer.