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. 2020 Apr 28;12(5):404. doi: 10.3390/pharmaceutics12050404

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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EGCG NPs inhibit activity of MMPs in endothelial cells. (A) Results of gelatin zymography from culture medium after 24 h incubation with a variant formulation for confirm the MMPs activity. (B) Quantification of MMP-2 and MMP-9 activities compared with the control group (n = 3). *p < 0.05 compared with control, ^#p < 0.05 compared with EGCG. Abbreviation: EGCG: epigallocatechin-3 gallate, HA: hyaluronic acid, RGD: arginine-glycine-aspartic acid, GE: Gelatin/EGCG self-assembling nanoparticles (NPs), GEH: GE NPs with HA surface coating, GEH-RGD: GE NPs with HA-RGD surface decoration, MMP: metalloproteinase.

EGCG NPs inhibit activity of MMPs in endothelial cells. (A) Results of gelatin zymography from culture medium after 24 h incubation with a variant formulation for confirm the MMPs activity. (B) Quantification of MMP-2 and MMP-9 activities compared with the control group (n = 3). *p < 0.05 compared with control, ^#p < 0.05 compared with EGCG. Abbreviation: EGCG: epigallocatechin-3 gallate, HA: hyaluronic acid, RGD: arginine-glycine-aspartic acid, GE: Gelatin/EGCG self-assembling nanoparticles (NPs), GEH: GE NPs with HA surface coating, GEH-RGD: GE NPs with HA-RGD surface decoration, MMP: metalloproteinase.