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. 2020 Apr 28;12(5):404. doi: 10.3390/pharmaceutics12050404

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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EGCG NPs inhibit neovessels formation in chemical cauterization-induced corneal neovascularization (NV). (A) Representative images of normal cornea, cauterized cornea and PBS-, EGCG-, GEH-, or GEH-RGD-treated cornea on day 7 following chemical cauterization. (B) The area of blood vessels in the cornea was quantified (n = 6). *p < 0.05 compared with PBS, ^#p < 0.05 compared with EGCG and GEH. Abbreviation: PBS: Phosphate buffer saline, EGCG: epigallocatechin-3 gallate, HA: hyaluronic acid, RGD: arginine-glycine-aspartic acid, GE: Gelatin/EGCG self-assembling nanoparticles (NPs), GEH: GE NPs with HA surface coating, GEH-RGD: GE NPs with HA-RGD surface decoration.