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. 2020 Apr 28;12(5):404. doi: 10.3390/pharmaceutics12050404

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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GEH-RGD NPs inhibit the expression of angiogenic factors in the cauterized cornea. Mice received chemical cauterization and were treated with PBS, EGCG, GEH NPs, GEH-RGD NPs-contained eye drops once daily for 7 days. The corneas were harvested and homogenized, and the protein level of (A) VEGF or (B) MMP-9 were assayed by ELISA (6 eyeballs/group from two batches). (*p < 0.05 compared with control, ^&p < 0.05 compared with PBS, ^#p < 0.05 compared with EGCG, ^>p < 0.05 compared with GEH). Abbreviation: PBS: Phosphate buffer saline, EGCG: epigallocatechin-3 gallate, HA: hyaluronic acid, RGD: arginine-glycine-aspartic acid, GE: Gelatin/EGCG self-assembling nanoparticles (NPs), GEH: GE NPs with HA surface coating, GEH-RGD: GE NPs with HA-RGD surface decoration. MMP: metalloproteinase, VEGF: vascularization endothelium growth factor, ELISA: enzyme-linked immunosorbent assay.