Figure 4.

Gross-pathology assessed at necropsy. The occurrence and extent of tuberculous disease pathology were recorded at necropsy using a standardised scoring system. This approach was used to determine total pathology scores from a range of pulmonary and extra-pulmonary tissues (A,B), lung pathology derived from scores assessed in each lung lobe (C,D), and an extra-thoracic score comprised of scores recorded from tissues typically associated with bacterial dissemination (E,F). Plots A, C and E show scores recorded from specific tissues in each individual animal, whereas plots B, D and F display summed tissue scores with group median values indicated. Animals that met humane end-point criteria are indicated with red data points. Significant differences between groups determined by Mann–Whitney U-test are shown.